BCHE 395-11 2013 Enzymes Intro

The equilibrium constant for the reackon linked to g

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Unformatted text preview: heory E + S ⇌ [ES ⇌ES⧧⇌EP] ⇌ E + P •  Chemical reacKons DO NOT occur instantaneously •  Always intermediates before final product formed •  Intermediates are highly energe8c (when compared to substrate and products) •  Can think of them with “parKally broken” (stretched) bonds and “parKally formed” new bonds, exisKng in the same intermediate •  Can plot a reacKon TransiKon state ethanol Ethyl- bromide commons.wikimedia.org/wiki/File:TransiKon_State.png 19 TransiKon State •  This symbol denotes transiKon state: ⧧ •  Remember: TransiKon state structure of a substrate is not that of either the substrate (S) or product (P) •  It is at a higher energy and energe8cally unstable with respect to both S and P 20 Is the reacKon spontaneous or nonspontaneous? Is the reacKon exergonic or endergonic? Does the equilibrium favor S or P? What about the REVERSE reacKon? What about rate? ReacKon Coordinate Diagram •  Magnitude of the ac8va8on energy represents the energy barrier and determines the rate of the reacKon •  ΔG’°= standard free energy change for the ground state of S and P does NOT change...
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This note was uploaded on 03/02/2014 for the course BIOCHEMIST 395 taught by Professor Potenza during the Spring '14 term at NMSU.

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