BCHE 395-18 2014 Biosignaling II

Binding and phosphorylagon of protein irs 1 insulin

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Unformatted text preview: Insulin Stimulation of: -glucose uptake -glycolysis -glycogen synthesis Low Glucagon -Inhibit glycolysis -Stimulates glycogen breakdown -Stimulates gluconeogenesis Enzyme- linked Membrane Receptors •  Many membrane receptors consists of: –  extracellular ligand- binding domain, and of –  intracellular catalyGc domain •  The most common catalyGc domains have the tyrosine kinase acGvity –  Adds a phosphate group to itself; auto- phosphorylaGon leads to a conformaGonal change allowing binding and cataly6c phosphoryla6on of specific target proteins –  Adds a phosphate group to a tyrosine in specific target proteins •  Some catalyGc domains have guanylyl cyclase acGvity –  Convert GTP to cGMP, a secondary messenger Receptor Tyrosine Kinases Insulin: The Hormone for Glucose Uptake and Metabolism •  Insulin is a pep6de hormone produced in the pancrease by the β- cells of islets of Langerhans –  Insulin is produced and released from the pancreas in response to nutrients such as glucose • ...
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