10-28-13 Secretory Pathway II questions

Calnexin is a type i transmembrane protein where is

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Unformatted text preview: attached? Describe the calnexin/calreticulin protein folding cycle. Where does it occur inside the cell? What sugars are present on proteins that bind calnexin/calreticulin? What roles do calnexin/calreticulin play in promoting protein folding? Calnexin is a type I transmembrane protein. Where is its N- terminus located with respect to the ER (does it face the cytoplasm or the ER lumen)? If a protein is correctly folded following its interaction w/ calnexin/calreticulin, what happens next? If a protein is incorrectly folded following its interaction w/ calnexin/calreticulin, what happens next? Why is a glycosyl transferase needed at this step? What happens if the protein fails to be folded after several rounds of the calnexin cycle? What triggers this? What types of lipids are synthesized in the ER? Where...
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This document was uploaded on 03/02/2014.

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