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Unformatted text preview: s of these enzymes are. flux controled by availability of materials
the more material you put in the more
acetyl COA comes from pyruvate dehydrogenase Man cannot live on fatty acids alone Fatty acids Fatty acids can't convert fatty acids to carbohydrates Anapleurotic (greek, filling up)
reactions replenish intermediates. Most important in mammals: Plants & bacteria can use a modified citric
acid cycle, the glyoxylate cycle, to synthesize
carbohydrates from acetyl CoA. Net reaction: 2 Acetyl CoA + 2 NAD+ + FAD + 2H20 heme ring acetyl CoA allosterically activates Fatty acids cannot be used to achieve
net synthesis of carbohydrates glucose gluconeogenesis gluconeogenesis oxaloacetate + ADP + Pi + 2 H+ 18 only 2 copies of kinase on the protein complex glucose pyruvate carboxylase Kinase & phosphatase
are bound to E2 core,
act on a specific Ser
residue of E1 17 Cycle intermediates are drained off for biosynthetic reactions - the cycle is "amphibolic". pyruvate + CO2 + ATP + H20 A nonequilibrium reaction regulated several ways (see book) Focus on feedback inhibition by NADH & acetyl...
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