Lecture+18+Citric+acid+cycle notes

Flux controled by availability of materials the more

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Unformatted text preview: s of these enzymes are. flux controled by availability of materials the more material you put in the more fuel=acetyl coA acetyl COA comes from pyruvate dehydrogenase Man cannot live on fatty acids alone Fatty acids Fatty acids can't convert fatty acids to carbohydrates Anapleurotic (greek, filling up) reactions replenish intermediates. Most important in mammals: Plants & bacteria can use a modified citric acid cycle, the glyoxylate cycle, to synthesize carbohydrates from acetyl CoA. Net reaction: 2 Acetyl CoA + 2 NAD+ + FAD + 2H20 heme ring acetyl CoA allosterically activates Fatty acids cannot be used to achieve net synthesis of carbohydrates glucose gluconeogenesis gluconeogenesis oxaloacetate + ADP + Pi + 2 H+ 18 only 2 copies of kinase on the protein complex glucose pyruvate carboxylase Kinase & phosphatase are bound to E2 core, act on a specific Ser residue of E1 17 Cycle intermediates are drained off for biosynthetic reactions - the cycle is "amphibolic". pyruvate + CO2 + ATP + H20 A nonequilibrium reaction regulated several ways (see book) Focus on feedback inhibition by NADH & acetyl...
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This note was uploaded on 03/02/2014 for the course BIOLOGY 101 taught by Professor Hayes during the Spring '09 term at Harvard.

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