Lecture+18+Citric+acid+cycle notes

Substrate from e1 and moves it to e3 9 10 many copies

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Unformatted text preview: ) that picks up substrate from E1 and moves it to E3 9 10 many copies of each of 3 polypeptides Pyruvate dehydrogenase acetyl CoA + CO2 + NADH pyruvate + NAD+ + CoA Reaction 1: pyruvate dehydrogenase E1 Thiamine = vitamin B1 B1 deficiency causes beriberi 11 don't need to learn names of subunits 12 Reaction 2: Also catalyzed by E1 Reactions 4 & 5 use the electron carrier FAD=flavin adenine dinucleotide • Lipoamide on a long flexible arm. Riboflavin: = vitamin B2 covalent bond • Lipoamides from different E2's pass acetyl groups to each other. exception(normally FADH2 has lower electron transfer potential) free rotation around each bond AMP • Allows all 60 E2 subunits to transfer acetyl groups to just 12 E3 units. not all of the 60E2 can be next to the 12 E3 can pass acetyl around until next to E3 When bound to pyruvate dehydrogenase, FADH2 has a higher e- transfer potential than NADH. FAD accepts 2 electrons and 2 protons 13 14 α-ketoglutarate dehydrogenase rxn is analogous to pyruvate dehydrogenase rxn Multienzyme c...
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This note was uploaded on 03/02/2014 for the course BIOLOGY 101 taught by Professor Hayes during the Spring '09 term at Harvard.

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