Lecture+18+Citric+acid+cycle notes

Substrate from e1 and moves it to e3 9 10 many copies

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ) that picks up substrate from E1 and moves it to E3 9 10 many copies of each of 3 polypeptides Pyruvate dehydrogenase acetyl CoA + CO2 + NADH pyruvate + NAD+ + CoA Reaction 1: pyruvate dehydrogenase E1 Thiamine = vitamin B1 B1 deficiency causes beriberi 11 don't need to learn names of subunits 12 Reaction 2: Also catalyzed by E1 Reactions 4 & 5 use the electron carrier FAD=flavin adenine dinucleotide • Lipoamide on a long flexible arm. Riboflavin: = vitamin B2 covalent bond • Lipoamides from different E2's pass acetyl groups to each other. exception(normally FADH2 has lower electron transfer potential) free rotation around each bond AMP • Allows all 60 E2 subunits to transfer acetyl groups to just 12 E3 units. not all of the 60E2 can be next to the 12 E3 can pass acetyl around until next to E3 When bound to pyruvate dehydrogenase, FADH2 has a higher e- transfer potential than NADH. FAD accepts 2 electrons and 2 protons 13 14 α-ketoglutarate dehydrogenase rxn is analogous to pyruvate dehydrogenase rxn Multienzyme c...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern