PreLecture 11 Genetic Analysis_Problem SolvingII_1to18 by UPAD

# PreLecture 11 Genetic Analysis_Problem SolvingII_1to18 by UPAD

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Lecture 10 Gene,c Analysis aka Problem Solving 1. How do we determine parental genotypes from the results of crosses and vice versa (when we know parental genotypes how do we anIcipate what phenotypic and genotypic raIos we will observe in the next generaIon)?
1. Students should be able to perform a complete geneIc analysis of a data set (results of a cross; pedigrees), which includes: ‐Using the results of crosses to establish the minimum number of genes and alleles involved in determining the phenotype of interest; ‐Determine dominance relaIonships and/or other interacIons among alleles of a gene; ‐Determine the respecIve genotypes of all the individuals menIoned in the data set and, for individuals with ambiguous genotypes, calculate the respecIve probabiliIes of genotype opIons; ‐Use informaIon from your analysis to calculate the probability of a parIcular genotype or phenotype being inherited. 2. Use the scienIfic method to solve problems: systemaIcally come up with a predicIon, test it, and keep it or reject it. 3. Given a problem, idenIfy what is known and what informaIon is needed to solve it. Learning Outcomes

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Problem‐solving process Data: What does the quesIon tell you? Hypothesis: What is an explanaIon that might be consistent with the data? How will you determine if your hypothesis/solu3on is valid? Show how you will check your work. Check: Does your result (based on your hypothesis) support or explain the data given in the quesIon? Checking revealed errors or inconsistencies Modify hypothesis & try again Checking validated hypothesis. Are there any valid alternaIves? You’re done! YES Are there errors? NO
Caenorhabditus elegans: wildtype , 2 different mutants: dumpy, uncoordinated Three crosses were performed (A, B, and C) between Dumpy and Uncoordinated worms The 100 F1 offspring for cross A is shown below A: 51 long, normal crawlers 49 dumpy, normal crawlers Use your worksheet to go through problem solving : what does the informaIon given in the quesIon tell you?

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