Lecture notes 9

Nadph fmn fad also has p450 site nos domains

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: structure to a glove. •  Binds substrates arginine and O2 and contains: –  a thiol bound heme group is accessible to solvent; O2 and Arg bind nearby –  tetrahydrobiopterin molecule. –  Structurally important anion, sulfate or phosphate which adjusts 2nd structure –  Zn(II) ion which resides at the dimer interface. NOS  ­ two dis8nct domains •  N ­terminal Arg oxidase is similar in NOS  ­ two dis8nct domains •  C ­terminal collector of electrons •  Binds mobile NADPH, released as NADP+ •  Bound cofactor molecules are all bound c...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online