Lecture notes 9

Nadph fmn fad also has p450 site nos domains

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Unformatted text preview: structure to a glove. •  Binds substrates arginine and O2 and contains: –  a thiol bound heme group is accessible to solvent; O2 and Arg bind nearby –  tetrahydrobiopterin molecule. –  Structurally important anion, sulfate or phosphate which adjusts 2nd structure –  Zn(II) ion which resides at the dimer interface. NOS  ­ two dis8nct domains •  N ­terminal Arg oxidase is similar in NOS  ­ two dis8nct domains •  C ­terminal collector of electrons •  Binds mobile NADPH, released as NADP+ •  Bound cofactor molecules are all bound c...
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