Lecture notes 2

Mitochondrial funcfon in normal and diabefc cells

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (superstoichiometric sFmulaFon of pyruvate oxidaFon by the various intermediates, and parFcularly citrate, succinate, α ­KG) •  Pulled forward by hydrolysis of bound intermediate (citrylCoA) BiosyntheFc consideraFons... •  DuFes: ImplicaFons of those duFes •  They may betray the origins of the cycle in anaerobic bacteria Mitochondrial funcFon in normal and diabeFc β ­cells PIERRE MAECHLER AND CLAES B. WOLLHEIM Figure 1 A map of human mitochondrial DNA indicaFng diabetes ­associated mutaFons. The mito genome encodes 37 genes (16,569 bp): 13 polypepFdes, 22 tRNAs. 2 ribosomal RNAs The polypepFdes are consFtuents of the respiratory ­chain complexes: 7 complex I subunits, 1 complex III subunits, 3 subunits of complex IV, 2 subunits of complex V The genes for tRNAs are presented as one ­lejer symbols. MutaFons in four of these tRNA genes are associated with diabetes: those for leucine (L), serine (S), lysine (K) and glutamic acid (E) tRNAs. Mitochondrial funcFon in normal and diabeFc β ­cells PIERRE MAECHLER AND CLAES B. WOLLHEIM Figure 2 The TCA cycle and respiratory chain in a mitochondrion. Substrate oxidaFon in the TCA cycle acFvates the respiratory chain, leading to the generaFon of ATP, which is subsequently transloca...
View Full Document

This document was uploaded on 03/01/2014 for the course CHEM 330 at Amherst College.

Ask a homework question - tutors are online