Strong stimulation can fire the postsynaptic cell

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Unformatted text preview: the excitatory postsynaptic potential (EPSP), after brief (~1 sec) and strong stimulation (tetanus). Strong stimulation can fire the postsynaptic cell while weak stimulation cannot. 30 min LTP and NMDA channels The N-methyl-Daspartate (NMDA) channels require both glutamate and postsynaptic deplorization to open up, which conditions normally imply simultaneous activation of both the pre- and the postsynaptic neurons. Ca2+ influx through open NMDA channels eventually leads to a strengthened synapse. Long-Term Depression (LTD) Strong stimuli can lead to enhanced synapse or long-term potentiation (LTP) as described above, whereas weak stimuli can lead to weakened synapse or long-term depression (LTD). LTD was first found in the cerebellar parallel-fiber to purkinje cell synapse. The example shown at the left comes from the hippocampal CA3 to CA1 synapse. Spike-timing-dependent plasticity LTD LTP LTP (strengthened synapse) if presynaptic input precedes postsynaptic spike. LTD (weakened synapse) if presynaptic input follows postsynaptic spike. Temporal Hebb rule has been found in tectum, cerebellum, hippocampus, and neocortex. (Poo) Place Field Follows Learned Visual Landmark Basic properties of place cells: •  Place cell firing is determined primarily by spatial location •  Cues for spatial location come from multiple sensory modalities and self-motion •  Rapid learning of landmarks within a few minutes Morris water maze: Remembering...
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