This preview shows page 1. Sign up to view the full content.
Unformatted text preview: the
potential (EPSP), after
brief (~1 sec) and strong
Strong stimulation can
fire the postsynaptic cell
while weak stimulation
cannot. 30 min LTP and NMDA channels
The N-methyl-Daspartate (NMDA)
channels require both
glutamate and postsynaptic deplorization
to open up, which
activation of both the
pre- and the postsynaptic neurons.
Ca2+ influx through
leads to a
synapse. Long-Term Depression (LTD)
Strong stimuli can lead to
enhanced synapse or long-term
potentiation (LTP) as described
above, whereas weak stimuli can
lead to weakened synapse or
long-term depression (LTD). LTD
was first found in the cerebellar
parallel-fiber to purkinje cell
synapse. The example shown at
the left comes from the
hippocampal CA3 to CA1
synapse. Spike-timing-dependent plasticity LTD LTP LTP (strengthened synapse) if presynaptic input
precedes postsynaptic spike.
LTD (weakened synapse) if presynaptic input
follows postsynaptic spike.
Temporal Hebb rule has been found in tectum,
cerebellum, hippocampus, and neocortex.
(Poo) Place Field Follows Learned Visual Landmark Basic properties of place cells:
• Place cell firing is determined primarily by spatial location
• Cues for spatial location come from multiple sensory modalities and self-motion
• Rapid learning of landmarks within a few minutes Morris water maze: Remembering...
View Full Document
- Spring '14