Zhang 2013-5

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Unformatted text preview: a good place •  •  Learning the location of a platform hidden under opaque water requires intact hippocampus. The spatial information come from sensory cues outside of the maze and from self-motion Drugs that block synaptic plasticity (long-term potentiation mediated by NMDA channels) impair behavioral learning. Long Term Potentiation (LTP) and NMDA Receptor Gene Knockout NMDA receptor is responsible for the associative LTP in CA3 to CA1 synapses. The synaptic strength, as measured by the excitatory postsynaptic potential (EPSP), can stay increased over 1 hour after only 1 second of strong stimuli. Knockout mice that lack one subunit of NMDA receptor in CA1 (dark band in the slice above) have defective LTP (left), unstable place fields, and cannot learn Morris water maze. Place cell plasticity: Asymmetric expansion effect explained by Hebbian learning last lap 1st lap Hippocampal place fields on a track with a rat running continuously back and forth Firing rate (recorded neuron) Running direction location CA1 place field expands and shifts backwards. Red curve: 1st lap Blue curve: last lap (Mehta) Review: supervised learning in a perceptron Output: y = ∑ wi xi i where input pattern: x1, x2, x3, … weig...
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This document was uploaded on 02/28/2014 for the course BME 580.402 at Johns Hopkins.

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