Homework 5 Solution 2011

P a 126 kg total body weight 61 tall 56 year old man

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Unformatted text preview: Theophylline) J.P., a 126-kg (total body weight), 6’1’’ tall, 56-year-old man, is seen in the emergency department with asthma that is unresponsive to inhaled bronchodilators and epinephrine. Estimate an IV loading dose and maintenance dose (expressed as dosing rate) of theophylline that will produce a theophylline concentration of 10 mg/L. J.P. suffers from CHF and smokes 2 packs of cigarettes a day. Thus, J.P. is obese. Use IBW to calculate CL and VD. J.P. could finally be convinced to stop smoking and lost 30kg. How would you have to adjust his loading dose and maintenance dose (expressed as dosing rate)? Patient is non-obese. Use TBW. Page 3 of 5 Problem 4 (Theophylline) J.D. is a 2-year-old, 9 kg male child in the hospital who is placed on a theophylline drip at 1 g/kg/hr after first receiving a 5 mg/kg bolus at 1 pm. The infusion is discontinued at 7pm. Plasma concentration samples were obtained at 2pm and 8pm. Could you use the Chiou equation to estimate his clearance? Explain why or why not. It is not possible to use the Chiou-equation to estimate his clearance because the last sample was not obtained...
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