This preview shows page 1. Sign up to view the full content.
Unformatted text preview: Theophylline)
J.P., a 126-kg (total body weight), 6’1’’ tall, 56-year-old man, is seen in the emergency
department with asthma that is unresponsive to inhaled bronchodilators and epinephrine.
Estimate an IV loading dose and maintenance dose (expressed as dosing rate) of theophylline
that will produce a theophylline concentration of 10 mg/L. J.P. suffers from CHF and smokes
2 packs of cigarettes a day. Thus, J.P. is obese. Use IBW to calculate CL and VD. J.P. could finally be convinced to stop smoking and lost 30kg. How would you have to adjust
his loading dose and maintenance dose (expressed as dosing rate)?
Patient is non-obese. Use TBW. Page 3 of 5 Problem 4 (Theophylline)
J.D. is a 2-year-old, 9 kg male child in the hospital who is placed on a theophylline drip at 1
g/kg/hr after first receiving a 5 mg/kg bolus at 1 pm. The infusion is discontinued at 7pm.
Plasma concentration samples were obtained at 2pm and 8pm. Could you use the Chiou equation to estimate his clearance? Explain why or why not.
It is not possible to use the Chiou-equation to estimate his clearance because the last
sample was not obtained...
View Full Document
- Spring '08