biomaterials hw 3 complete

5mgml and igm 005mgml of igm of transferrin

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Unformatted text preview: ! M!!"#!! = 12.4!"# = 2.0584×10!!" ! !!" =surface area of Cyt ­c=4/3π!! ! =(4/3)π*0.18(10!!) )=7.53982*10!!" !! !  =100μg/mg of microparticles=0.0001g/mg of microparticles !"# Average MW of microspheres 50,000 ­70,000 !!"" =!!"#$%&' /!!" ∗ !  (the effective area/molecules adsorbed) !"# !!" !!"" =(2.0584*10 !)/[(7.53982 ∗ 10!!" !!) (0.0001g/mg of particles)] =2.73004*10!! mg/!! 2.) Synovial fluid includes albumin [5 mg/ml], transferring [0.5mg/ml], and IgM [0.05mg/ml]. !! of IgM>!! of transferrin>!! of albumin. i. Initially the protein with the highest concentration, albumin, will occupy the majority of the surface sites very quickly. Transferrin will also start to accupy some sites immediately but at a slower rate. The maximum concentration of transferrin on the surface will never reach the maximum concentration of albumin. In the beginning, minimal IgM will adsorb to the surface because the concentration is so low that there is not enough to get to the sites quickly enough. However, as time goes on the affinity of the protein to the material becomes more important than the concentration in the solution. The transferrin and the IgM start replacing the albumin on the surface site...
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