Chem E2a-Lecture 6-Annotated-2013

C predict the product of the following reaction oh 1

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Unformatted text preview: 7.4f Predict the product of the following reaction: OH 1. SOCl2, pyr 2. NaI I A.  a 47% 41% I B.  b Cl 9% D.  d d b a Cl c 3% C.  c Predict the product of the following reaction: OH 1. PBr3 2. NaCN Br A.  a Br 81% B.  b CN d c b 3% a 4% CN D.  d 12% C.  c Making Alcohols Leave: PuPng It Together •  What reagents are needed to carry out the following transformations? H CH3 OH H 1. CH3 2. 3. 7 Reading: Section 7.4f Synthesis of Ethers: Williamson Ether Synthesis •  You already know all of the routes for synthesizing ethers! Let’s review the mechanism: NaOH R SH R' R LG S R a thiolate NaH R OH + LG R' + LG a sulfide R' R R' S O LG R an alkoxide O an ether •  Using only alcohols as starting materials, synthesize the following ether: O Desired Product 8 Reading: Section 7.10b Synthesis of Cyclic Ethers: Intramolecular Williamson Ether Synthesis •  Draw a curved-arrow mechanism and predict the product of the following re...
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This document was uploaded on 01/29/2014.

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