Lecture 2 - Cell organization function and communication

msh mc1r gs adenylase cylcase atp camp pde4d3 amp wnt

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Unformatted text preview: Acetylcholine Receptor 18 Signaling molecules (ligands) •  Small molecules (e.g. glutamate or histamine) or small proteins (e.g. ACTH) that are released to the extracellular region Signaling receptors •  Binds to the ligand and transduces the signal from the extracellular domain to the intracellular domain –  Extracellular receptors •  Have an extracellular domain (binds to ligand), transmembrane domain (anchors it to membrane) and intracellular domain (traduces the signal to the inside) –  Intracellular Receptors •  Ligand is able to cross membrane and binds a receptor inside the cell •  Upon binding receptor traduces signal 19 Example of extracellular receptors G ­protein coupled receptors: •  Intracellular domain of receptor bound to a G ­ protein •  A G ­protein binds to GTP and GDP, but its only ac2ve when bounded to GTP •  Example: Ac2va2on of MC1R by alpha ­MSH !-MSH MC1R G!S Adenylase cylcase ATP cAMP PDE4D3 AMP Wnt Pathway P-CREB Lef1 MITF p16INK4a p27 CYDCCDK4 RB Pigment Related Proteins p15 C...
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