Lecture 2 - Cell organization function and communication

Adhesive fibronec2n and laminin structural collagen

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Unformatted text preview: CYDCCDK4 RB Pigment Related Proteins p15 CDK2 E2F p21 p-p53 TBX2 p19ARF Cell Cycle Progression Apoptotic Factors BAX DCT, TYR, TRPM1, MART1, AIM-1, Silver and PDE4D caspase BCL2 MDM2 Apoptosis 25 Cellular Structure 26 Tissue and organs •  Tissue –  Group of cells with similar structure or func2on •  Epithelial, connec2ve, nervous and muscle •  Organs –  Collec2on of two or more 2ssues that performs a physiological func2on 27 Mul2cellular Organisms •  Single organisms composed of more than one cell •  Main benefit from the division of labor •  Each cell have a different func2on and therefore different shape •  Specialized cells need to be able to communicate and a^ached to adjacent cells 28 Mul2cellular Organisms •  Have Extracellular Matrix (ECM) that provides support and connect cells •  Cells junc2ons connect cells with each others and to ECM •  Between ECM, cell junc2ons and adhesive molecules keeps mul2cellular organisms together 29 Extracellular Matrix (ECM) •  Extracellular matrix helps to support and organize cells •  Major component are proteins and polysaccharides •  Roles –  –  –  –  –  strength structure Support organiza2on cell signaling 30 Proteins of the extracellular matrix •  Adhesive –  Fibronec2n and laminin •  Structur...
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This document was uploaded on 03/05/2014.

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