Lecture 2 - Cell organization function and communication

Lecture 2 Cell organization function and communication

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Unformatted text preview: DK2 E2F p21 p-p53 TBX2 p19ARF Cell Cycle Progression Apoptotic Factors BAX DCT, TYR, TRPM1, MART1, AIM-1, Silver and PDE4D caspase BCL2 MDM2 Apoptosis 20 Example of extracellular receptors G ­protein coupled receptors: 21 Example of extracellular receptors Protein Kinase Receptors: •  Extracellular domain of receptor binds to ligand •  Receptor dimeriza2on occurs upon ligand binding •  The cross phosphoryla2on that occurs between receptor provide a “scaffold” where other proteins can be recruited (bind) •  Important for blood clokng, human development and cell division •  Example: EGFR ac2va2on by Epidermal Growth Factor 22 Example of extracellular receptors Protein Kinase Receptors: •  Example: EGFR ac2va2on by Epidermal Growth Factor 23 Signal transduc2on Changes that can occur upon ac2va2on of a signaling pathway: •  Conforma2onal change –  Phosphoryla2on of tyrosine, serine or threonine –  Other protein modifica2ons •  Change in protein ­protein interac2on •  Degrada2on 24 What if cell signaling goes wrong? •  It is crucial for the cell to control the regula2on of cell signaling •  Misregula2on of a signaling pathway can lead to diseases like cancer !-MSH MC1R G!S Adenylase cylcase ATP –  Melanoma cAMP PDE4D3 AMP Wnt Pathway P-CREB Lef1 MITF p16INK4a p27...
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This document was uploaded on 03/05/2014.

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