Lecture 2 - Cell organization function and communication

G microlia change in the shape of cells polarity 57

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: will bind to each other 47 Proteins in anchoring junc2ons  ­ Cadherins •  If individual cells of different 2ssue (or specimen) are mixed together they would segregate according to their 2ssue type A. Different types of sponges B. Different 2ssue 48 Proteins in anchoring junc2ons  ­ Cadherins •  If individual cells of different 2ssue (or specimen) are mixed together they would segregate according to their 2ssue type 49 Proteins in anchoring junc2ons – Integrins Focal adhesion •  Do not require Ca2+ to func2on •  Transmembrane protein: Extracellular domain binds to ECM and cytoplasmic domain binds to cytoskeleton (Focal adhesion) •  Different integrins will bind to a specific ECM •  Plants have integrin ­like proteins 50 Proteins in anchoring junc2ons – Focal adhesion •  Uses integrins •  Bind to laminin and other ECM protein •  Couple ECM to cytoskeleton 51 Tight Junc2ons •  Junc2ons between adjacent cells in a layer that prevent the leakage of material between cells •  Forms 2ght seal between adjacent cells •  Make the layer that cover many 2ssues and organs, e.g. diges2ve track, respiratory track and skin •  Tight junc2on proteins: Occluding and Claudin 52 Gap junc2ons •  Channels that permit the direct exchange of ions and small molecules between the cytosol of adjacent cells 53 Cytoskeleton •  Generate and maintains cellular shape •  Composed of microfilaments, microtubules and, for some organisms, intermediate filaments 54 Cytoskeleton ...
View Full Document

This document was uploaded on 03/05/2014.

Ask a homework question - tutors are online