Lecture 6 - Cardiovascular and Respiratory Systems

Conforma7onal change that makes hemoglobin to have

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Unformatted text preview: gs 14 Tidal gas exchange  ­ humans •  Air comes in and exhaled gases flow out through the same route •  Nasal (oral) cavity – pharynx – trachea – bronchiole – alveoli 15 Tidal gas exchange  ­ humans •  Inhaling and exhaling are caused by changes within the thoracic cavity –  Thoracic cavity: a closed compartment where lungs are suspended bounded by a sheet of muscle call diaphragm –  Inhaling: contrac7on of diaphragm causes expansion of thoracic cavity, which pulls on the lungs –  Exhaling: Relaxa7on of diaphragm 16 Red blood cells •  Red blood cells –  Are anucleated cells •  To have more room to carry oxygen 17 Oxygen carrying molecules •  Transporta7on of gases –  O2 dilu7on in blood plasma is low –  Molecules that have high binding affinity towards O2 •  Picks up O2 at high pressure and releases O2 at low pressure •  Hemoglobin in red blood cells picks up O2 •  Four binding sites, first binding increases the likelihood of second binding event (working coopera7vely) 18 Oxygen carrying molecules •  First O2 molecule binds causing a conforma7onal change that makes hemoglobin to have higher affinity for second O2 molecule to bind •  The binding of the third molecule of O2 causes the opposite e...
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