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Chapter 7-BB -intro

Gradient electrochemical atp synthase atp enzyme

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Unformatted text preview: ATP synthase ATP Enzyme harnesses free energy as H+ flow through membrane embedded region through Energy conversion- H+ electrochemical gradient or proton motive force converted to chemical bond energy in ATP to Racker and Stoeckenius confirmed ATP Racker uses an H+ electrochemical gradient uses Rotary machine that makes ATP as it Rotary spins spins Yoshida and Kinosita demonstrated that the γ subunit of the ATP synthase spins of Masasuke Yoshida, Kazuhiko Masasuke Kinosita, and colleagues set out to experimentally visualize the rotary nature of the ATP synthase rotary Released membrane embedded Released portion and adhered it to a slide portion Visualize g subunit using Visualize fluorescence fluorescence Added ATP to make reaction run Added backward backward Rotated counterclockwise to Rotated hydrolyze ATP hydrolyze – Rotate clockwise to synthesize Rotate ATP ATP Cancer cells usually favor glycolysis Cancer Many disease associated with Many alterations in carbohydrate metabolism metabolism Warburg effect- cancer cells Warburg preferentially use glycolysis while decreasing oxidative ph...
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