3 cutaneous malignant melanoma

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Unformatted text preview: ...... 3 Cutaneous Malignant Melanoma ............................................................................ 5 Melanoma Tumor Progression ............................................................................... 5 Melanoma Risk Factors........................................................................................... 7 Pathways Involved in Melanoma Biology ............................................................... 8 RAS Signaling Pathway .......................................................................................................................9 RAS-RAF-ERK SIGNALLING ..................................................................................................................... 10 RAS-PI3 K-AKT SIGNALING ...................................................................................................................... 11 RAS-RAL SIGNALING ................................................................................................................................ 11 OTHER EFFECTORS O F RAS SIGNALI NG PATH WAY ..................................................................................... 12 RB and p53 Pathways............................................................................................ 13 Mutations in Oncogenes and Suppressor Genes in Melanoma ............................ 13 Chromosomal Abnormalities in Melanoma ......................................................... 17 Susceptibility Genes in Melanoma ........................................................................ 18 Cooperation of RAS and CDKN2A ...................................................................... 20 RAS and Cell Cycle Regulation ............................................................................ 21 RAS and Cell Invasion .......................................................................................... 22 RAS in Differentiation, Growth Arrest and Senescence ...................................... 23 Oncogenic RAS and Human Cancer ....
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