New Perspectives on Melanoma_ The Role of PAX3

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Unformatted text preview: ................. xv List of tables ......................................................................................................................................... xvi List of abbreviations ........................................................................................................................ xvii Chapter I ­ Thesis overview ............................................................................................................ 1 i. GENERAL INTRODUCTION .................................................................................................. 1 Cutaneous malignant melanoma .......................................................................................... 1 PAX3 transcription factor ........................................................................................................ 1 Significance of the study ......................................................................................................... 2 ii. LITERATURE REVIEW ........................................................................................................... 4 1. Melanocytes: Development and function ............................................................. 4 1.1. Melanocyte development: From neural crest through melanoblasts to melanocytes ............................................................. 4 Melanocytic origin and embryonic development ................................. 4 Regulation of melanocyte development: Role of Pax3 during embryogenesis ........................................................................... 6 The central role of Pax3 in melanocyte differentiation ....................... 7 1.2. Melanocytes of the adult skin ........................................................................ 9 1.3. Melanocyte function: Regulation of melanogenesis ......................... 11 Melanocyte signalling pathways ............................................................... 14 2. Melanoma ........................
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