New Perspectives on Melanoma_ The Role of PAX3

108 limitationsofthestudy

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ....................................................................... 92 Selection of potential PAX3 target genes ..................................................... 93 Chapter V ­ General discussion ............................................................................................. 96 PAX3 expression in melanocytic lesions and normal skin ............................... 96 PAX3 in normal skin melanocyte ................................................................................ 97 PAX3‐regulated melanocyte differentiation network ........................................ 99 Significance of PAX3 expression in normal melanocytes ............................... 100 Differential mechanisms of PAX3 regulation in melanoma ........................... 103 Proliferative vs. aggressive motile melanoma cell phenotype and how does PAX3 fit into this ........................................................................................ 105 Chapter VI – Conclusion .......................................................................................................... 108 Limitations of the study ................................................................................................. 108 Future directions .............................................................................................................. 109 References ...................................................................................................................................... 113 Appendix ......................................................................................................................................... 134 xiv List of Figures LIST OF FIGURES Figure 1.1.1. Neural crest formation and diversification ................................................... 5 Figure 1.1.2. Pax3 expression during embryonic development ...................................... 7 Figure 1.1.3. Schematic representation of regulation of melanogenic gene expression ....................................................................
View Full Document

Ask a homework question - tutors are online