New Perspectives on Melanoma_ The Role of PAX3

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Unformatted text preview: .................................................................................................. 18 . Melanoma origin and progression ....................................................................... 19 3. PAX3 expression in melanoma and other neural crest derived malignancies ..................................................................................... 23 iii. SUMMARY ................................................................................................................................. 24 iv. RESEARCH DESIGN, HYPOTHESIS AND AIMS ........................................................ 27 Chapter II ­ Medic and Ziman, 2009 ........................................................................................ 31 Abstract ....................................................................................................................................... 32 Introduction .............................................................................................................................. 33 Melanocyte development during embryogenesis ..................................................... 34 Key factors in melanocyte development ....................................................................... 36 xii Table of Contents Melanocyte stem cells in the adult skin ................................................................... 38 . Multifunctional role of Pax3 during melanocyte development and maturation ................................................................................................................. 39 Pax3 and maintenance of the undifferentiated state ......................................... 40 Antiapoptotic role for Pax3 ........................................................................................... 41 Pax3 role in migration ..................................................................................................... 42 Pax3 function in differentiated melanocytes ...............................
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This document was uploaded on 03/06/2014 for the course CHEMISTRY 12 at National University of Singapore.

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