New Perspectives on Melanoma_ The Role of PAX3

49 conclusion

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Unformatted text preview: ............................. 43 Regulation of Pax3 function .......................................................................................... 44 Function determined by Pax3 levels ......................................................................... 45 PAX3 expression in melanoma .................................................................................... 46 . PAX3 role(s) in melanoma ............................................................................................. 46 Opposing role(s) of PAX3 and MITF in melanoma .............................................. 47 PAX3 and BRAF‐regulated pathways in melanoma ............................................ 49 Isoform mediated roles ................................................................................................... 49 Conclusion ............................................................................................................................. 50 Acknowledgement ............................................................................................................. 51 Chapter III ­ Medic and Ziman, 2010 ................................................................................. 52 Abstract .............................................................................................................................. 53 Introduction ......................................................................................................................... 54 Results .............................................................................................................................. 56 PAX3 expression in normal skin, naevi and melanoma ......................... 56 Characterisation of PAX3‐positive cells: Co‐expression of PAX3 and MITF ......................................................................................................... 59 PAX3 in melanocyte differentiation: Co‐expression of PAX3 with MITF, HES1 and MLANA ......................
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