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New Perspectives on Melanoma_ The Role of PAX3

In addition mitf and dct known pax3 targets in the

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Unformatted text preview: gical Sciences, Iowa City, IA 52242. Author Contributions Conceived and designed the experiments: SM MZ. Performed the experiments: SM. Analysed the data: SM MZ. Contributed reagents/materials/analysis tools: SM MZ. Wrote the paper: SM. Edited the paper: MZ. 76 Chapter IV – Medic, Rizos and Ziman, 2011 Chapter IV EXPERIMENTAL ARTICLE Differential PAX3 functions in normal skin melanocytes and melanoma cells Authors and Affiliations Sandra Medic1, Helen Rizos2 and Mel Ziman1,3* 1School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, WA, Australia, 2Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead Millennium Institute, Westmead, NSW, Australia, 3School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia * Corresponding author A/Prof. Mel Ziman School of Exercise, Biomedical and Health Sciences Edith Cowan University Joondalup Campus PH: +61‐8‐63045171 Fax: +61‐8‐63045717 E‐mail: [email protected] Citation: Medic S, Rizos H, Ziman M (2011) Differential PAX3 functions in normal skin melanocytes and melanoma cells. Biochem Biophys Res Commun 411: 832‐ 837. Impact factor (2010): 2.59 ERA rank (2010): B 77 Chapter IV – Medic, Rizos and Ziman, 2011 Abstract The PAX3 transcription factor is the key regulator of melanocyte development during embryogenesis and is also frequently found in melanoma cells. While PAX3 is known to regulate melanocyte differentiation, survival, proliferation and migration during development, it is not clear if its function is maintained in adult melanocytes and melanoma cells. To clarify this we have assessed which genes are targeted by PAX3 in these cells. We show here that similar to its roles in development, PAX3 regulates complex differentiation networks in both melanoma cells and melanocytes, in order to maintain cells as “stem” cell‐like (via NES and SOX9). We show also that mediators of migration (MCAM and CSPG4) are common to both cell types but more so...
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