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New Perspectives on Melanoma_ The Role of PAX3

Itislikelyto regulate other cellular processes at

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Unformatted text preview: d by ChIP‐sequencing [281] and/or are significant to melanoma development [229] (Table S1). Our final list included 12 genes potentially regulated by PAX3 in melanocytes and/or melanoma cells (Table S1), in addition to the MITF and DCT. Table S3. Potential PAX3 target genes. Gene Gene description and function Gene expression PAX3 binding Melanoma top genes Genes involved in melanocytic differentiation: MITF Microphthalmia associated transcription factor (D) TYR Tyrosinase (D) TRP1 DCT / TRP2 Tyrosinase related protein 1 (D) Down [204] χ [282] Dopachrome tautomerase (D) Down [19] HES1 Hairy and enhancer of split 1 (D) SRY (sex determining region Y)‐ box 9 (D) Nestin (D) Cbp/p300‐interacting transactivator 1 (D, P) Up [122] χ [282] Down [122] χ [280] χ [280] Up [121,280] SOX9 NES CITED1/ MSG1 Up [64,65] χ [282] Genes involved in proliferation and cell cycle regulation: CCNA1 Cyclin A1 (P, Ap) Up [121] CCNA2 Cyclin A2 (P) Up [121] χ [280] CCNE1 Cyclin E1 (P) Up [121,204] TPD52 Tumour protein D52 (P, anti‐Ap) Up [121] χ [280] c‐KIT C‐kit receptor (P, D, M) Up [121] KITL KIT ligand (P, Ap, M) Up [121,280] APOD Apolipoprotein D (P, D) Up [121] **(59th) [229] **(5th) [228] *(45th) [228] 93 Chapter IV – Medic, Rizos and Ziman, 2011 Growth factors involved in proliferation and angiogenesis: TGFβ1 TGFβ2 TGFα FGF1 FGF2 FGF8 FGF10 FGF17 FGFR1 IGF1R VEGFC Transforming growth factor‐beta isoform 1 (P, Ap, M) Transforming growth factor‐beta isoform 2 (P, Ap, An, EMT) Transforming growth factor‐alpha (P) Fibroblast growth factor 1 (P, Ad) Fibroblast growth factor 2 (P, Ap, An, M) Up [121] χ [280] Up [204] Χ [281] Up [57] Up/down [121] Up [121] Χ [281] χ [280] Χ [279] χ [280] Fibroblast growth factor 8 (P, An) Fibroblast growth factor 10 (P, An, M) Fibroblast growth factor 17 (P, D, M) Up [121] Fibroblast growth factor receptor 1 (P, D) Up/down [121] Insulin‐like growth factor 1 receptor (P, M, anti‐Ap) Vascular endothelial growth factor C (An, M, P) **...
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