New Perspectives on Melanoma_ The Role of PAX3

Presumably the most likely explanation is that the

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Unformatted text preview: (62nd) [228] χ [280] Χ [279] Χ [279] χ [280] Genes involved in apoptosis: NF‐Kβ2 BCL2L1 PTEN MDM1 TIMP2 TIMP3 Nuclear factor kappa B 2 (p100) (anti‐Ap) BCL2 like protein 1 (anti‐Ap) Phosphatase and tensin homologue deleted from chromosome 10 (Ap) Mdm1 nuclear protein homologue (mouse) (Ap) Tissue inhibitor of metalloproteinase 2 (An, D, P) Tissue inhibitor of metalloproteinase 3 (Ap, An) Up [204] χ [280] Up [226] χ [280] Down [197] χ [280] Χ [279] Up [121] Up [121,204]/ down [280] **(120th) [228] χ [280] Genes involved in migration and adhesion: CSPG4/ MCSP MCAM/ MUC18 Chondroitin sulphate proteoglycan 4 / HMW‐MAA (M, An) Melanoma cell adhesion molecule (M, Ad) CXCR4 CXC chemokine receptor 4 (M) EPHA2 EPHA4 EPHB2 χ [280] Up [121,204] χ [280] Χ [279] χ [280] Ephrin type‐A receptor 2 (M) Ephrin type‐A receptor 4 (M) Down [280] Up [280] Χ [279] Down [280] Χ [279] VCAM1 Ephrin type‐B receptor 2 (M) Vascular cell adhesion molecule (Ad) S100A6 Calcium binding protein A6 (M, P) Up [121] χ [280] VCAN Versican (V2 splice variant) (Ad) Up [204] **(21st) [228] Χ [279] 94 Chapter IV – Medic, Rizos and Ziman, 2011 CNR1 Cannabinoid receptor type 1 (Ap, Im, ) Up [280] χ [280] EMT (epithelial to mesenchimal transition): CDH3 CDH5 CDH12 Cadherin 3 type 1/ P‐cadherin (Ad) Cadherin 5 type 2/ VE‐cadherin (Ad) Cadherin 12 type 2/ N‐cadherin 2 (Ad) Χ [279] *(3rd) [228] Χ [279] Χ [279] Cancer specific genes: PRAME MAGEC3 MAGEA5 MAGEB6 MAGEB18 Melanoma antigen preferentially expressed in tumours (P, anti‐Ap) Melanoma antigen family C, 3 (ND) Melanoma antigen family A, 5 (ND) Melanoma antigen family B, 6 (ND) Melanoma antigen family B, 18 (ND) Up [204] **(4th) [228] Χ [279] Χ [279] **(28th) [228] Χ [279] Χ [279] Other genes: MGP DMRT2 ST8SIA1 NAA10 CD55 WNT5B Matrix gla protein (D, M) Doublesex and mab‐3 related transcription factor 2 (D) ST8 alpha‐N‐acetyl‐neuraminide alpha‐2,8‐sialyltransferase 1 (P) N (alfa)‐acetyletransferase 10 (P, anti‐Ap) Complement decay‐accelerating factor (anti‐Ap, Im) Wingless‐type MMTV integration site family, member 5B (D, M, An) Down [204] Χ [279] χ [280] **(20th) [228] Χ [279] Up...
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