New Perspectives on Melanoma_ The Role of PAX3


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Unformatted text preview: sses in melanoma cells, PAX3 may contribute to development of malignant melanocytic lesions and disease progression. Moreover its expression and action in normal melanocytes may confer upon them a less differentiated, proliferative and motile phenotype, thus predisposing them to aggressive malignant transformation. Results presented here provide avenues for exploring PAX3 as a potential tool for developing targeted therapy for melanoma treatment. vi Acknowledgements ACKNOWLEDGEMENTS I would first like to thank to my supervisor Mel, for guidance and endless support, optimism and patience. I am most thankfull however to my family, especially my dear Petar and Helena, for the patience and support through this (what seemed sometimes like a never‐ending) journey. Finally, I would like to thank to my colleagues and friends for the assistance and encouragement. vii Preface PREFACE Policy Content: A PhD by publication shall conform to Rule 52 plus the following: (i) completion of the requirements for Confirmation of Candidature (Rule 34); (ii) a full explanatory introduction, general discussion and conclusion shall be included to link the separate papers and to place them in the context of an established body of knowledge; (iii) if an adequate contextual literature review is not otherwise presented, it shall be included as a separate chapter; (iv) if detailed data and descriptions of methods are not otherwise given, they shall be included as appendices; (v) only papers published in refereed scholarly media during the period of enrolment may be included in a thesis submitted in the form of a series of published papers. However, papers which have been accepted for publication but have not yet appeared in refereed scholarly media may also be included as part of the thesis; (vi) the number of papers submitted should be sufficient for the body of work to constitute a substantial and original contribution to knowledge; (vii) any published paper of which the candidate is a joint author may only be included in the thesis provided the work done by the candidate is clearly identified. The candidate must provide to the University Research Students and Scholarships Committee, at the time of submission of the thesis, a written statement from each co­author att...
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This document was uploaded on 03/06/2014 for the course CHEMISTRY 12 at National University of Singapore.

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