New Perspectives on Melanoma_ The Role of PAX3

Factor receptor chondroitin sulphate proteoglycan 4

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Unformatted text preview: PAX3 “target” gene expression levels in melanocyte and melanoma cells ....................................................................................................... 86 xv List of Tables LIST OF TABLES Table S1. Selected PAX3 target genes included in the custom promoter binding qPCR array .................................................................................................. 92 Table S2. Primers used in RT‐qPCR analysis .................................................................... 92 Table S3. Potential PAX3 target genes ................................................................................. 93 xvi List of Abbreviation LIST OF ABBREVIATIONS αMSH ACTH AKT ATCC BAX BCL2L1 BRAF BRN2 CCNA2 CCND1 CDK4 ChIP c‐Met CSPG4 CXCR4 DCT DKK1 DMEM DNA DSHB EDNRB ET FBS FGF FGFR GAPDH GRG4 HDAC10 HDM2 HES1 HGF LEF1 IgG IP α melanocytes stimulating hormone, currently designated as propiomelanocortin (POMC) adenocorticotropic hormone serine/threonin protein kinase AKT American Type Culture Collection BCL2‐associated X protein BCL2 like protein 1, also known as BCL‐XL v‐raf murine sarcoma viral oncogene homologue B1 PUO class 3 homeobox 2 (POU3F2) cyclin A2 cyclin D1 cyclin‐dependant kinase 4 chromatin immuno‐precipitation met proto‐oncogene, also known as hepatocyte growth factor receptor chondroitin sulphate proteoglycan 4, also known as MCSP, and HMW‐MAA CXC chemokine receptor 4 dopachrome tautomerase, also known as tyrosinase‐related protein 2 (TYRP2) dickkopf homologue 1 Dulbecco’s Modified Eagle Medium deoxyribonucleic acid Developmental Studies Hybridoma Bank endothelin receptor type B endothelin foetal bovine serum fibroblasts growth factor fibroblasts growth factor receptor glyceraldehydes‐3‐phosphate dehydrogenase groucho 4, currently designated as transduction‐like enhancer of split 4 (E (sp1) homologue, Drosophila) (TLE4) histone deacetylase 10 currently known as Mdm2 p53 binding protein homologue (MDM2) hairy and enhancer of split 1 hepatocyte growth factor lymphoid enhancer‐binding factor 1 immunoglobulin G immunoprecipitation xvii List of Abbreviation KIT MAPK MC1R MCAM MITF MLANA NES NF‐Kβ2 NGS NRAS p16 PAX3 PMEL PRAME PTEN...
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