Lipophilic hormones cross the membrane and bind with

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Unformatted text preview:   hydrophilic hormones; highly water soluble, low lipid solubility, can’t be absorbed if taken orally for supplementa&on •  lipophilic hormones; highly lipid solubility, poorly soluble in water, can be taken orally Hormone Ac&ons •  Hydrophilic hormones bind with surface membrane receptors. •  Why not intracellular targets? •  Trigger a chain of intracellular events by means of a second- messenger pathway. •  Lipophilic hormones cross the membrane and bind with receptors inside the cell. •  Influence gene ac&vity, altering synthesis of intracellular proteins •  May also interact with membrane receptors Extracellular (first) messenger (Activates) GDP GTP ECF Plasma membrane G- protein- (Activates) coupled receptor Second messenger G- protein- intermediary 2 1 Adenylyl cyclase (effector protein) ICF 3 Inactive protein kinase A Active protein kinase A 4 Inactive designated protein (changes shape and function) Active designated protein 5 Key Phosphate Cellular response Fig. 4-25, p. 125 ECF Blood vessel Plasma protein carrier Steroid hormone Plasma membrane Cytoplasm Cellular response 1 9 Portion t...
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This note was uploaded on 03/06/2014 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Winter '08 term at UC Davis.

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