Genetics HW#11 - process 2 Elongation occurs when the next...

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Not surprisingly a number of antibiotics that are used to fight bacterial infections do so by interfering with various steps in the translational process in bacteria (but have little or no effect on translation in eukaryotic cells, and so do not have a toxicity problem). If you were working as a scientist in a pharmaceutical company trying to develop a new antibiotic to use to fight bacterial infection, what are three steps in bacterial translation that you could target? 1. Initiation of translation: involves the small subunit of the ribosome binding to 5' end of mRNA with the help of initiation factors (IF), other proteins that assist the
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Unformatted text preview: process. 2. Elongation: occurs when the next charged tRNA in line binds to the ribosome along with an elongation factor. It is the lengthening of the growing polypeptide chain by one amino acid. 3. Termination: occurs when the A site of the ribosome faces a stop codon (UAA, UAG, or UGA). When this happens, no tRNA can recognize it and therefore no amino acids are added, but a releasing factor can recognize nonsense codons and causes the release of the polypeptide chain....
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