Unformatted text preview: ells. leukemia is B cell cancer. N Engl J Med
August 25, 2011 Study Overview
leukemia • A patient with refractory CLL had delayed development of the rapid
tumor lysis syndrome and remission after an infusion of T cells
engineered to express an antigen receptor capable of recognizing B
cells (CD19) coupled to two signaling molecules. outcome of patient- ten months later still in remission. No B cells and hypoExpansion and Persistence of Chimeric Antigen Receptor T Cells In Vivo.
gammaglobinemia are both seen ten months after treatment.
CD5 another molecules
most B cells use kapa mostely
killed the B cells. it would
decrease and thus
immunosuppressant. risk benefit
Transfer pooled gammaglobulin
that would cover wide range of
most b cells have kapa
bcells with kapa light chain. doesnt have antibodies Porter DL et al. N Engl J Med 2011;365:725-733 Prostate Cancer Treatment With Sipuleucel-T and it contains GM-CSF A chimeric protein containing GM-CSF [activates
APCs] plus Prostatic Acid Phosphatase [PAP] was transfected
only be presented as class 1
The median survival time with sipuleucel-T was 25.8 months
compared to 21.7 months for control group.
There was no difference in tumor progression! Melanoma- gp 100 or glycoprotein 100 * class 1 gene. Melanoma patients with an HLA allele called A 0201 are given
a peptide intramuscularly that consists of nine amino
acids (209-217 or 280-288) from MAGE (melanoma
associated antigen) glycoprotein. May
also receive simultaneously interleukin 2, an immune stimulatory
Drawback is patients must have inherited correct
HLA allele for this particular “vaccine” to work.
Various reports* indicate that one year survival with gp100 is
minimally different from control patients.
*Rosenberg SA et al, Nat Med 2004; 10:909-915. Use of monoclonal antibodies in cancer immune therapy -mab is a monoclonal antibody prevents shutting down Ipilimumab (brand name is yervoy)-an antibody that blocks
CTLA-4, a molecule expressed by T cells.
Tregs Blocking of cytotoxic T- ly...
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12