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Oncogenesis oncogenes translocations oncoviruses

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Unformatted text preview: nslocations • Oncoviruses Oncogenes Oncogenes (Rous Sarcoma Virus- v-src) Alteration of several proto-oncogenes can lead to colon cancer APC, DCC and p53 are all involved in inhibiting the cell cycle; K-ras is involved in cell signaling Translocations Translocation of Proto-oncogene can lead to B cell lymphoma Oncoviruses Retroviruses may induce cancer by inserting into the genome a defective c-onc (e.g. v-src- a tyrosine kinase). DNA viruses such as Human Papilloma Viruses 16 and 18 may induce oncogenesis by inhibiting tumor suppressor genes such as Rb and p53 or by activation of growth receptors (e.g. PDGFR) Human Oncoviruses 1.Epstein-Barr Virus- Burkitt’s lymphoma (B cell lymphoma)-DNA 2. Hepatitis B and C- Hepatocellular Carcinoma-DNA, RNA 3. Human T-lymphotropic virus- T cell leukemia-Retrovirus-works by producing TAX which interferes with IκB 4. Human Papilloma B Virus 16 and 18- Cervical, anal and oral cancers –DNA (can cause activation of PDGFR + produces E6,7) 5. Human Herpes Virus 8- Kaposi’s Sarcoma -cancer of lymphatic endothelium-DNA 6. Merkel Cell Polyomavirus- Merkel cell carcinoma of the skinDNA TATAs on melanoma cells MAGE-1,2, 3 ; BAGE; GAGE-1,2 are oncofetal antigens normally only expressed on testis germ- line cells. Tyrosinase, gp100, Melan-A, MART-1 and gp75 are overexpressed on Melanoma cells and maybe breast tumors, non-small cell lung tumors, head and neck carcinomas, gliomas 40% of human melanomas are MAGE-1 + and 75% are MAGE-2 or 3 + Kuby 6th edition...
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