11.+Immune+Respone+to+Cancer+1+slide

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Unformatted text preview: th immunological molecules that may enhance the anti-tumor immune response * PLAM = poly-lactic acid microspheres; Sabel et al, Breast Cancer Res Treat:122 325-336, 2010 * PLAM = poly-lactic acid microspheres; Sabel et al, Breast Cancer Res Treat:122 325-336, 2010 PLAM = poly-lactic acid microspheres; Interleukin 12 and Tumor Necrosis Factor (TNF) are molecules produced by various cells involved in the immune response. * % Survival Sabel et al, Breast Cancer Res Treat:122 325-336, 2010 Active Clinical Trials of Cancer Treatment Vaccines by Type of Cancer: Bladder Cancer Brain Tumors Breast Cancer Cervical Cancer Hodgkin Lymphoma Kidney Cancer Melanoma Multiple Myeloma Leukemia Lung Cancer Non-Hodgkin Lymphoma Pancreatic Cancer Prostate Cancer From FDA website: http://www.cancer.gov/cancertopics/factsheet/Therapy/cancer-vaccines Following are background slides that describe the basic cell biology of cancer. You do not need to know the information on these slides for the course. They are posted here as a matter of general interest. SK Interleukin-2 and diphtheria toxin (Denileukin Difitox) may be useful in treating Cutaneous T –cell Lymphomas and possibly melanomas. The drug may work by binding to IL-2 receptors on T cell lymphomas and Treg cells. Cell Biology of Cancer Classification of Cancer Types Carcinoma- Cancers arising from epithelial tissue (e.g. breast, colon, lung, prostate). Adenocarcinomas arise from glandular tissue. Sarcoma- Cancers arising from connective tissue, mesenchyme or mesoderm (e.g. bone, muscle) Hematopoietic- Cancers arising from bone marrow cells (e.g. leukemia, lymphoma) Normal Cell Cycle Cyclin has to bind to Cdk to activate the kinase. Once activated, Cdk triggers cell-cycle events CDK are usually expressed at constant levelsCyclins wax and wane throughout the cell cycle APC/C = anaphase promoting complex/ cyclosome, part of ubiquitin- protein degradation system; destroys securin, allowing chromatids to separate 2 steps involves in the activation of Cdk’s p27 is a CdKI p53 causes blockage of CDK2 and other CDK’s; p53 increases the activity of p20 which binds to CDK2 and decreases its activity. Oncogenesis • Oncogenes • Tra...
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