Unformatted text preview: rogression. Khong and Restifo: Nature Immunology 3: 999; 2002 darwinian selection of tumor cells that are less express TRAs(immune can kill off those that express a lot) and thus immune system may
aid this selection thus allowing escapes. Darwinian selection of tumor
cells with low expression
of class I MHCs-the three E’s * the tumor is not an
immunogenic immune system making TGF beta Tumor
T cells and suppress
TGF -beta but an
angiogenic factor Manipulation of Immune System to
Treat Cancer B7 binds to the CD28 and thus cause more killing. doesnt work very well. can downregulate the B7
tumor cells does not have enough TRA the antigen.
because of the darwinian selection. Transfection of tumor cells with B7 More dendritic cells. the tumor still didnt have enough TRAs. `
increase GM-CSF that increases APCs skip Role of Tregs in Cancer
Tregs downregulate/inhibit the immune system.
Takes out IL2 and starve effector T cells
out competes the T cells. Treg Treg tumor burdened cells
A lot more Tregs in the tumor
burdened mouse int he healthy
mouse. TGF-beta by angiogenic
factor. BALB/c mice were injected with 1 x 105 4T1 mammary tumor cells.
dLN= tumor draining lymph nodes
nLN = normal lymph nodes of tumor free mice Darrasse-Jeze et al J Clin Invest V 119: Number 9 September 2009 number of Tregs in non-draining (ndLN) and draining lymph nodes of tumor
inoculated mice getting rid of the regulatory T cells and thus survival is more sucessful in the antiCD25
the problem is that we can get a decrease in the tumor burden but you are once again TREGS negative. Original Article: Brief Report
Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
David Porter , MD, Bruce Levine, PhD, Michael Kalos, PhD, Adam Bagg, MD and Carl June , MD use cytotoxic B cells. only have MHC2 and replace the T cell receptor with the antibody. will bind to a TRA in a B cell.
took out the TC receptor. CD 19 is associated with B c...
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