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Unformatted text preview: an kill Th cells via perforin and granzyme B pathways (Treg may need to
bind to target cells in order to exert their effects, though this is not certain)
Treg induce the negative co-stimulatory molecule B7-H4 on APCs (unknown ligand
on Th cells)
(some of the above information comes from Zou 2006- Nature Reviews
Immunology 6:295-307) PMN- =neutrophils-no inate response
Scid, RAG- mouse and no severe combined immuno deficiency. no b or t cels
T/B- no adaptive response Innate Immune Response and Inflammation Hogeman factor produced by the liver. is there in the body as well as the clotting factor and only when needed does it become activated
endothelial layer. carbohydrates and glycoaminoglyicans. have a high negative charge. Activate Fibrin bclod. converting Fi rinogen to
fibrin. then gets degrades by another cascade plasmin.
Bradykinin(powerful molecule) activate pain fibers. violate
cruel unusual punishment.
degranulate mast cells-histamines
epithelial has kerotinocytes activate dedritic cells and defensins
Hageman factor is floating around and circulating in the blood
but only activated when it is exposed to extracellular
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12