12.+HIV+1+slide

Establishing apoptosis pathways and the degrivation

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Unformatted text preview: of CD4 cells by cytotoxic lymphocytes (i.e. CD 8 cells). Might be destruc.on of lympha.c .ssue by chronic viral inflamation destroys lymphatic tissues infec.on. Soluble gp120 could bind to CD4 on thymocytes blocking posi.ve selec.on gp120 bind to the CD4 on the thymocytes blocking positive selection. Forma.on of Synci.a between infected CD4 T cells and uninfected CD4 T cells via gp120 and CD4 (especially seen in CXCR4 HIV variants) both can do this clumps CD4 bb 7 bj   5. Increased expression of TRAIL Receptors on CD4 cells and TRAIL on Dendri.c Cells CXCR4 and CCR5 is both HIV. kills of CD4 cells. kill off your CD4 cells. pDC restricts the dendritic cell. the percent of pDC = Plasmacytoid Dendritic Cells Hep 1 TRAIL = Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Stary et al: Blood 114:3854-3863, 2009 upregulate the Trail receptor in T cell so and the trail in the Dentritic to cause apoptosis to T cells AT = aldrithiol-2 (an oxidizing agent that renders HIV noninfectious but still able to penetrate target cells) Cells are CD4 T cells TRAIL R1 and R2 = activator receptors of apoptosis TRAIL R3 and R4 = decoy receptors for TRAIL Stary et al: Blood 114:3854-3863, 2009 one of the ways the the CD4 cells being killed, when it is infected y HIV. establishing apoptosis pathways. and the degrivation of DNA measures apoptosis TUNEL shows apoptosis BDCA 2+ is a C lectin found on dendritic cells. TUNEL = Transferase mediated dUTP nick-end labeling- measures degree of apoptosis Treatment of HIV nucleotied and screw up the reverse transcriptase. inhibit fusion called Maraviroc and Fuzeon blocks gp41 (Raltegravir) (Maraviroc - An. CCR5) (Fuzeon- Blocks gp41) Indinavir Drug Strategies for Figh0ng HIV Without drug treatment maternal to child transfer (MTCT) of HIV is around 15-30%; transmission via b...
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.

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