8.+Cytokines+1+slide

Il 2 interferon ifn family ifn il 10 chemokine family

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Unformatted text preview: eceptors The 4 cytokine families – based on structure ①  Hematopoietin family §༊  IL-2, IL-4, IL-12, IL-23 etc the largest group. IL-2 ②  Interferon (IFN) family §༊  IFN-γ, IL-10 ③  Chemokine family §༊  CCL5 (RANTES), CCL8 (IL-8) ④  Tumor necrosis factor (TNF) §༊  TNF-α IFN-γ Found at Tufts. original cytokine. called the fever molecule. The OC -- IL-1 “The fever molecule” IRAK The OC -- IL-1 “The fever molecule” Receptor for IL1 is IRAK. Dinarello et al. 2009. Annu. Rev. Immunol Selected Innate Cytokines of Importance (and a few of my favorites) Cytokine IL-1 IL-1 TNF-α TNF-alpha I IL-6 L-6 Sundgren-Andersson, A et al 1998; Negishi, C 2003. (Primarily) Secreted by Targets and effects Monocytes, macrophages,Inflammation, fever, t helper cell develoment Monocytes, Macrophages Inflammation, fever, endo/epithelial cells (MΦ), endo/epithelial cells T helper cell development MΦ macrophage Inflammation, fever induction of Iapoptosis cachexia, neutrophil activation nflammation, fever induction of apoptosis, cachexia, neutrophil activation Fever, MΦ, DCs, endothelial cells Fever, inflammation, T helper cell, inflammation, development Macrophage, DCs, T helper cell endothelial cells development, antibody secretion Selected Adaptive Cytokines of Importance (a few more of my favorites) Cytokine IFN-γ IFN-gamma IL-4 and IL5 IL-4 & IL-5 Il-2 IL-2 (Primarily) Secreted by CD4 T cells-T helper (Th) 1, CD4 T cells – T helper NK cells, CD8 CTLs (Th) 1, NK cells, CD8 CTLs CD4 T cells-Th2 CD4 T cells – Th2, mast mast cells cells T cells T cells Targets and effects Macrophage activation, increase MHCI/II Mϕ activation, expression, Ag presentation increase MHCI/II expression, Ag presentation Th2 development, IgE class switching Th2 development, eosinophil activation IgE class switching, eosinophil activation Activates T cells Proliferation, autocrines NK activation, B cell proliferation Five families of cytokine receptors ①  Immunoglobulin (Ig) super family ②  Class I cytokine receptors (He...
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