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Unformatted text preview: factor-related apoptosis-inducing
ligand recptor*);FAS-FASL (negative regulators) skipped skipped Integrin dimer ? ? CD 28 is present but there is no B7 on target cells skipped
CTLA4 and tumor therapy
Ipilimumab (monoclonal against CTLA4) is
used in melanoma patients.
It extended life by 3.5 months but with severe
immune-related side effects. CTLA binding to B7
can increase the
production of indoleamine 2,3-dioxygenase (IDO) in APCs
which inhibits tryptophan
levels in T cells
(in order to
proliferate, T cells
need adequate am...
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12