5.+TCR+1+slide

cd 28 is present but there is no b7 on target cells

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: factor-related apoptosis-inducing ligand recptor*);FAS-FASL (negative regulators) skipped skipped Integrin dimer ? ? CD 28 is present but there is no B7 on target cells skipped CTLA4 and tumor therapy Ipilimumab (monoclonal against CTLA4) is used in melanoma patients. It extended life by 3.5 months but with severe immune-related side effects. CTLA binding to B7 can increase the production of indoleamine 2,3-dioxygenase (IDO) in APCs which inhibits tryptophan levels in T cells (in order to proliferate, T cells need adequate am...
View Full Document

This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.

Ask a homework question - tutors are online