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cd 28 is present but there is no b7 on target cells

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Unformatted text preview: factor-related apoptosis-inducing ligand recptor*);FAS-FASL (negative regulators) skipped skipped Integrin dimer ? ? CD 28 is present but there is no B7 on target cells skipped CTLA4 and tumor therapy Ipilimumab (monoclonal against CTLA4) is used in melanoma patients. It extended life by 3.5 months but with severe immune-related side effects. CTLA binding to B7 can increase the production of indoleamine 2,3-dioxygenase (IDO) in APCs which inhibits tryptophan levels in T cells (in order to proliferate, T cells need adequate am...
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