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Unformatted text preview: is present in humans). Associates with beta 2 microglobulin and activates
Class Ib MHC Molecules- MIC-A and MIC-B proteins are induced by
heat shock proteins, are expressed by epithelial cells and are recognized by
NK cells and by some gamma delta T cells*. These cells are then activated and kill
the MICA and MICB expressing cells. Does not associate with beta 2 microglobulin. *Most gamma delta T cells do not need antigens to be presented by any known
MHC or MHC- like molecules. For example, V gamma 9/V delta 2 human T cells
recognize directly a microbial compound,E-4-hydroxyl-3-methyl-but-2-enyl
pyrophosphate (HMB_PP) produced by organisms such as Mycobacteria
tuberculosis and plasmodium. CD 1 is not classical but associaed with Beta 2 microglobulin. very hydrophobic. CD1 looks like Class I, but associates with MIIC and therefore has
characteristics of MHC II. CD1 has a hydrophobic channel, ideal for the
binding of glycolipids. CD1 does associate with beta 2 microglobulin. group 2 group 1 Presentation of lipid epitopes by CD1- nonclassical
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12