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Unformatted text preview: ormed by alpha helically
alpha 2 gives the other wall
beta sheets are the floor. half comes from one
alpha nd then then the other is the other half another
chromosome CD8 binding antibodies are interested in
hydrogen bonding is not specific
and the * Binding cleft can bind to multiple antigens.
because of the anchor residues in the cleft can bind to the different peptides. as long as the anchor residue is bound to the peptide. MHC Class I Class one, if its too long it gets chopped shorter and if its short it would elongate it
the pocket is somewhat open so that it would extend beyond 2,3,6 are anchor residue anchor residues of antigenic peptides (8-10 amino acids for
Class I binding) 9. I and L are very similar. you can replace it with v as well and they are interchangeable because of the similarity. anchor residues of antigenic peptides MHC Class II antigenic peptide is 13-18 amino acids
for Class II binding
MHC Class II alpha 1 and 2 and alph3 form the binding cleft. the variability chain is many polypeptides bind to one anoth...
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12