Unformatted text preview: ntibodies against this sugar because a lot of bacteria has this sugar. α 1,3 glactosyl epitope and α 1,3 galactosyltransferase =sugar negative Galactosyl Primates does not present this. Xenograft get an organ from another species, and we reject them very vigorously because it express this sugar
Titer Abalpha 1, 39 high amounts of anitbody against this sugar. melonoma cells becoming encrusted with melanoma
melanoma vaccine A. Lungs from B16 Neo vaccinated
mice A melanoma don't have this sugar. both of them have the
mice have that enzyme but we knock it out. vaccinate both groups with
melanoma cells a has no sugar and b has the sugar. we treated them both
with melanoma without sugar. but the B's activated T cells will attack the
melanoma without the sugar.
Antibodies bind to the sugar
positive vaccine and causes
complement and opsinization,
and as it dies it releases
heatshock proteins. and as the
cells get taken up by the MHC B. Lungs from mice injected with
B16 alpha Gal vaccine Alpha gal showed
double positive is expressed invitro. chart Gated CD8 cells derived f...
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This document was uploaded on 03/10/2014 for the course BIOLOGY 104 at Tufts.
- Fall '12