Unformatted text preview: ents who then present injected
FGG with their own APCs and MHC molecules).
testing a secondary response.congenic the background doesnt matter. skip Kimball _3rd edition Intro to Immunology skip
Percentage of Labeled Peptide Bound To Labeled Peptide MHC of responders IAd IEd IAk IEk OVA 323-339 IAd 11.8 0.1 0.2 0.1 IAd 18.9 0.6 7.1 0.3 IAk 0.0 0.0 35.2 0.5 IEk 0.4 0.2 0.7 1.1 Myoglobin 132-153 IEd 0.8 6.3 0.5 0.7 Lamda repressor 12-26 IAd + IEk 1.6 8.9 0.3 2.3 HA 130-142
HEL 74-86 Negative selection? Equilibrium Dialysis plus for=maximum proliferation specific is to
T cell apc interation and respons are not specific but it is restricted.
right side is specificity based on the inhibition of the OVA specific IAD and how well the T cell receptor binds to the peptide presenting
IAD skip MIC A and MIC B in humans are nonclassical MHC molecules because they are no normally get involved with presentation. * Nonclassical class I
MHC molecules (M not
shown) Black letters represent
nonclassical Class I MHC
molecules MIC-A and MIC-B Nonclassical MHC Class I molecules
Class Ib MHC Molecules- H2-M3 can present N-formylmethionine (CHO=
formyl group), which is the amino acid that bacteria use to initiate protein
synthesis (this MHC molecule is present in mice, uncertain if this MHC molecule...
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- Fall '12
- MHC Class, Major histocompatibility complex, MHC class I