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001 vs placebo tnd 2005 galantamine maintains

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Unformatted text preview: label phase Month 12 Month 6 (194) (183) (173) (158) (146) (388) (354) (319) (285) (275) * p < 0.001 vs placebo. © TND 2005 Galantamine maintains Disability Galantamine Assessment for Dementia (DAD) scores Assessment in DAD from baseline Mean (± SE) change Galantamine 24 mg/day Placebo Improvement 2 1 0 -1 -2 -3 -4 -5 -6 Baseline * * p ≤ 0.002 vs placebo Deterioration 2 4 Time (months) 6 © TND 2005 Galantamine improves Neuro-Psychiatric Inventory (NPI) scores over 6 months Inventory Mean (± SE) change in NPI from baseline -2 Improvement -1 * 0 * p = 0.016 vs placebo 1 2 0 Baseline 2 4 6 Time (months) Galantamine 24 mg/day Deterioration Placebo © TND 2005 CI FOR VASCULAR DEMENTIA CI EVIDENCE: three RCT with donepezil and with galantamine showing efficacy in patients with AD & CVD or probable VaD CONTROVERSY: are CI acting on the AD component of VaD? RECOMMENDATION: treat vascular risk factors in all patients with dementia, consider a CI in mixed AD­VaD; need for more RCT in probable VaD © TND 2005 © TND 2005 DI...
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