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05 vs placeboreminyl and not statistically different

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Unformatted text preview: 1 2 3 4 5 6 7 0 3 6 Months 9 12 Deterioration Placebo/Reminyl® 24 mg *P <0 .05 vs Placebo/Reminyl® and not statistically different from baseline. Reminyl® 24 mg/Reminyl® 24 mg Historical placebo group © TND 2005 LS mean change from baseline ± SE Cognition: Severe Impairment Battery (SIB) p<0.0001 6 p=0.0051 p<0.0009 p=0.0078 4 p<0.0001 p=0.0001 Clinical improvement 2 0 Baseline -2 Donepezil -4 -6 Clinical decline Placebo 0 4 8 12 18 24 ITT LOCF Study week Donepeziln=139 130 115 123 119 120 (139) Placebo n=145 139 119 128 128 126 (145) © TND 2005 FUNCTIONAL OUTCOMES Disability Assessment in Dementia (DAD) © TND 2005 LS mean change from baseline ± SE Functional autonomy: Disability assessment for dementia (DAD) 4 Clinical improvement p=0.0037 2 p<0.0001 p<0.0001 0 Baseline -2 -4 Clinical decline -6 -8 Donepezil -10 Placebo -12 0 12 Study week 24 ITT LOCF Donepeziln=134 125 121 (134) Placebo n=140 129 126 (140) © TND 2005 BEHAVIOR OUTCOMES NeuroPsychiatric Inventory (NPI) Behave AD © TND 2005 Reminyl delays the emergence of behavioral symptoms Reminyl (Tariot: GAL-USA-10) (Tariot: Dose Increment –3 Improvement Dose Increment –2 –1 Mean (± SE) Change From Baseline In NPI * 0 1 2 3...
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