gauthier_therapy

Beer intellectualleisureactivitiessocialization

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Unformatted text preview: OR AD High education NSAIDS Statins Red wine, ? Beer Intellectual leisure activities, socialization ? Post menopausal hormonal replacement therapy © TND 2005 © TND 2005 THERAPEUTIC OBJECTIVES Control of existing symptoms by restoring cholinergic activity Delay progression of disease after diagnosis by modifying pathophysiology Delay emergence of symptoms in persons at risk © TND 2005 TRIAL DESIGNS TO TEST TRIAL SYMPTOMATIC BENEFIT SYMPTOMATIC Parallel groups over 3, 6 or 12 months Extended open­label observations Measure all relevant symptomatic domains: cognition, ADL, behavior, global impression of change. © TND 2005 COGNITIVE OUTCOMES Mini Mental State Examination (MMSE) Alzheimer Disease Assessment Scale – cognitive section (ADAS­cog) Severe Impairment Battery (SIB) © TND 2005 LS mean change from baseline (±SE) Mini-Mental State Examination Mini-Mental (MMSE) (MMSE) 2.5 2 Clinical improvement 1.5 p=0.053 1 P<0.001 p=0.019 0.5 p=0.001 P<0.001 0 Baseline -0.5 -1 -1.5 Clinical decline Donepezil -2 -2.5 Placebo -3 0 donepezil n= 135 placebo n= 137 12 127 128 24 36 Study week 121 120 52 Endpoint 104 105 91 98 (135) (137) © TND 2005 Reminyl maintains cognitive benefits in AD over 12 Reminyl months (Raskind GAL-USA-1/3) Double-blind –4 Open-Extension Improvement –3 –2 Mean (± SE) Change From Baseline in ADAS-cog Score –1 * 0...
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This document was uploaded on 03/07/2014 for the course BIOLOGY BIO at NYU.

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