Jakala_ParkSlides_Part_A

First described in 1912 by a german neuropathologist

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Unformatted text preview: ribed in 1912 by a German neuropathologist - Friedrich Lewy. Inclusions particularly numerous in the substantia nigra pars compacta. © TND 2005 TND Lewy bodies Lewy © TND 2005 TND © TND 2005 TND Neuropathology of PD: Lewy bodies Neuropathology Not limited to substantia nigra only; also found in the locus coeruleus, motor nucleus of the vagus nerve, the hypothalamus, the nucleus basalis of Meynert, the cerebral cortex, the olfactory bulb and the autonomic nervous system. Confined largely to neurons; glial cells only rarely affected. © TND 2005 TND Lewy bodies Lewy © TND 2005 TND Functional neuroanatomy of PD Functional Substantia nigra: The major origin of the dopaminergic innervation of the striatum. Part of extrapyramidal system which processes information coming from the cortex to the striatum, returning it back to the cortex through the thalamus. One major function of the...
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