Jakala_ParkSlides_Part_A

One major function of the striatum is the regulation

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: striatum is the regulation of posture and muscle tonus. © TND 2005 TND Substantia nigra and the extrapyramidal system Substantia CORTEX + + STRIATUM D1 D2 D1 GPe SNc − SNr + STN + GPi THALAMUS NORMAL MOTOR CONTROL © TND 2005 TND Neurochemistry of PD Neurochemistry Late 1950s: Dopamine (DA) present in mammalian Late brain, and the levels highest within the striatum. brain, 1960, Ehringer and Hornykiewicz: The levels of DA 1960, severely reduced in the striatum of PD patients. severely PD symptoms become manifest when about 50-60 % PD of the DA-containing neurons in the substantia nigra and 70-80 % of striatal DA are lost. and © TND 2005 TND Dopamine pathways in human brain Dopamine © TND 2005 TND Dopamine synthesis Dopamine © TND 2005 TND Therapy of PD: levodopa Therapy Late 1950s: L-dihydroxyphenylalanine (L-DOPA; Late levodopa), a precursor of DA that crosses the blood-brain barrier, could restore brain DA levels and motor functions in animals treated with catecholamine depleting drug (reserpine). drug First treatment attempts in PD patients wi...
View Full Document

This document was uploaded on 03/07/2014 for the course BIOLOGY BIO at NYU.

Ask a homework question - tutors are online