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Unformatted text preview: © TND 2005
TND Additional clinical features of PD
Additional Postural instability: Due to loss of postural reflexes. Dysfunction of the autonomic nervous system: Impaired
gastrointestinal motility, bladder dysfunction, sialorrhea,
excessive head and neck sweating, and orthostatic
hypotension. Depression: Mild to moderate depression in 50 % of patients. Cognitive impairment: Mild cognitive decline including
impaired visual-spatial perception and attention, slowness in
execution of motor tasks, and impaired concentration in most
patients; at least 1/3 become demented during the course of
© TND 2005
TND Neuropathology of PD
Neuropathology Eosinophilic, round intracytoplasmic inclusions called
lewy bodies and Lewy neurites. First desc...
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