Treatment symptomatic tnd 2005 tnd therapy of pd other

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Unformatted text preview: reatments Therapy DA receptor agonists DA (bromocriptine, pergolide, pramipexole, ropinirole, cabergoline) Amantadine Amantadine Anticholinergics © TND 2005 TND Diagnosis of PD Anamnesis and clinical examination Anamnesis No disease-specific biological marker available No Positron Emission Tomography (PET) or Singlephoton Emission Computed Tomography (SPECT) photon with dopaminergic radioligands Exclusion of several causes of secondary Exclusion Parkinsonism Parkinsonism © TND 2005 TND Summary Summary → 1-2 % of the general population over the age of 65 y Lewy bodies and Lewy neurites particularly in the substantia Lewy nigra pars compacta dopaminergic neurons projecting to striatum striatum DA levels severely reduced in striatum. Resting tremor, bradykinesia, muscle rigidity Levodopa and other dopaminergic drugs Levodopa No treatment which would prevent the continuous No degeneration of nerve cells in the substantia nigra and resulting striatal DA loss resulting No disease-specific biological marker © TND 2005 TND...
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